Email:
support-global@metwarebio.com
Mar 05, 2024
In the realm of cancer research, understanding the intricate dynamics of energy metabolism has become increasingly crucial. Energy metabolism, the process by which cells obtain and utilize energy, plays a pivotal role in cancer progression and therapy response. Targeted metabolomics, a powerful analytical approach, has emerged as a valuable tool in unraveling the complexities of energy metabolism in cancer. In this blog, we delve into the significance of energy metabolism-targeted metabolomics and its impact on cancer research.
Energy metabolism alterations are a hallmark of cancer cells, facilitating their rapid proliferation and survival in hostile environments. The Warburg effect, characterized by increased aerobic glycolysis even in the presence of oxygen, is a well-known metabolic adaptation observed in cancer cells. Additionally, dysregulated lipid metabolism and amino acid metabolism contribute to the energetic demands of cancer cells. Understanding these metabolic rewiring processes is crucial for identifying potential therapeutic targets and biomarkers in cancer.
![Figure_1._Energy-consuming_processes_during_migration_[1].png](/uploads/image/20240322/Figure_1._Energy-consuming_processes_during_migration_[1].png "Figure_1._Energy-consuming_processes_during_migration_[1].png")
Targeted metabolomics enables the precise quantification of specific metabolites involved in energy metabolism pathways. By employing advanced analytical techniques such as mass spectrometry and nuclear magnetic resonance spectroscopy, researchers can dissect metabolic pathways and identify aberrations associated with cancer development and progression. For instance, a study by DeBerardinis et al. (2008) highlighted the role of altered glucose metabolism in promoting tumorigenesis, underscoring the importance of targeted metabolomics in elucidating metabolic rewiring in cancer [2].
Energy metabolism-targeted metabolomics offers a myriad of applications in cancer research. It facilitates the discovery of novel metabolic biomarkers for early cancer detection and prognosis assessment. Moreover, by profiling metabolic signatures in tumor tissues and biofluids, researchers can stratify patients based on metabolic phenotypes, aiding in personalized treatment strategies. Additionally, targeted metabolomics enables the evaluation of metabolic responses to anticancer therapies, guiding the development of novel therapeutic interventions.
Energy metabolism-targeted metabolomics represents a powerful approach for dissecting the intricate metabolic rewiring underlying cancer development and progression. By providing insights into metabolic alterations, identifying potential biomarkers, and guiding therapeutic strategies, targeted metabolomics contributes significantly to advancing cancer research and improving patient outcomes.
For researchers and healthcare professionals seeking to delve deeper into the energy metabolism pathway and its impact on cellular functions, MetwareBio stands at the forefront of energy metabolism analysis services. Utilizing cutting-edge technologies and methodologies, MetwareBio provides comprehensive insights into energy metabolism, aiding in the advancement of health sciences and nutritional research. Explore our services and unlock the secrets of energy metabolism at MetwareBio's energy targeted panel.
Index | Compounds | Class |
1 | Pyruvic acid | Organic acid And Its derivatives |
2 | Serine | Amino acids |
3 | L-Glutamic acid | Amino acids |
4 | Threonine | Amino acids |
5 | Lysine | Amino acids |
6 | Tyrosine | Amino acids |
7 | Arginine | Amino acids |
8 | Ornithine | Amino acids |
9 | L-Leucine | Amino acids |
10 | Glutamine | Amino acid derivatives |
11 | L-Alanine | Amino acids |
12 | Succinic Acid | Organic acid And Its derivatives |
13 | Alpha-Ketoglutaric Acid | Organic acid And Its derivatives |
14 | L-Asparagine | Amino acids |
15 | Adenine | Nucleotide and Its metabolomics |
16 | Inosine | Nucleotide and Its metabolomics |
17 | 3-phenyllactic acid | Organic acid And Its derivatives |
18 | Citric acid | Organic acid And Its derivatives |
19 | Lactate | Organic acid And Its derivatives |
20 | ADP | Nucleotide and Its metabolomics |
21 | … | … |
Contact us for a full list.
2. Effect of heat and hypoxia stress on mitochondrion and energy metabolism in the gill of hard clam
1. Parlani, M., Jorgez, C., & Friedl, P. (2023). Plasticity of cancer invasion and energy metabolism. Trends in cell biology, 33(5), 388–402. https://doi.org/10.1016/j.tcb.2022.09.009
1. DeBerardinis, R. J., Lum, J. J., Hatzivassiliou, G., & Thompson, C. B. (2008). The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell metabolism, 7(1), 11–20. https://doi.org/10.1016/j.cmet.2007.10.002
