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Accurate compound identification
each metabolite has been developed using external standards;
Energy metabolism is the process of generating energy (ATP) from nutrients such as glucose and fatty acids to generate various metabolites, including those from glycolysis pathway (EMP), tricarboxylic acid cycle (TCA), and pentose phosphate pathway (PPP). Metware Biotechnology's Energy Metabolism Assay obtains absolute quantitative detection of 68 energy related metabolites from various fluid and tissue samples.
Energy metabolism is the process of anaerobic glycolysis and aerobic respiration from nutrients such as glucose and fatty acids for the production of energy (ATP). It is one of the most basic characteristics of life and maintains the basis of cellular function. Energy metabolism, also known as central carbon metabolism (CCM), mainly includes glycolysis pathway (EMP), tricarboxylic acid cycle (TCA), and pentose phosphate pathway (PPP). These pathways cycle through many intermediate compounds to generate energy. Metware Biotechnology uses QTRAP, a triple-quad LC-MS technology, to obtain absolute quantification of 68 metabolites associated with these pathways. One no longer have to guess how the cells or organism is doing, our assay will help quantifiy their energy uses and help you determine the affects of your experiment.
each metabolite has been developed using external standards;
the panel covers 68 compounds in the three major pathways;
using AB QTRAP® 6500+ LC-MS/MS for detection of ng/mL levels.
Build cohorts, do screening of differential metabolites, build diagnostic models and performance validation markers.
Do metabolite modulation and perform functional phenotype validation based on the screened target metabolite species.
Establish disease animal models and perform functional mechanism validation through multiple pathways.
It mainly contains compounds from the glycolytic pathway (EMP), the tricarboxylic acid cycle (TCA), and the pentose phosphate pathway (PPP).
Metware Biotechnology's Energy Metabolism Assay is an absolute quantitative method. Each substance is developed by an external standard, and the absolute quantitative value is calculated according to the standard curve.
Compounds | CAS No | Class |
Pyruvic acid | 127-17-3 | Organic acid And Its derivatives |
Serine | 56-45-1 | Amino acids |
L-Glutamic acid | 56-86-0 | Amino acids |
Adenine | 73-24-5 | Nucleotide and Its metabolomics |
Inosine | 58-63-9 | Nucleotide and Its metabolomics |
3-phenyllactic acid | 828-01-3 | Organic acid And Its derivatives |
Lactate | 50-21-5 | Organic acid And Its derivatives |
ADP | 58-64-0 | Nucleotide and Its metabolomics |
Uracil | 66-22-8 | Nucleotide and Its metabolomics |
Guanosine | 118-00-3 | Nucleotide and Its metabolomics |
c-di-AMP | 54447-84-6 | Nucleotide and Its metabolomics |
Cyclic-AMP | 60-92-4 | Nucleotide and Its metabolomics |
Fructose 1,6-bisphosphate | 34693-15-7 | Phosphate sugars |
NADPH | 53-57-6 | Carbohydrate metabolomics |
| Products | Sample Requirements |
| Serum/plasma | 100ul/sample, snap-frozen in liquid nitrogen and stored at -80°C. Ship on dry ice. Avoid thawing. |
| Tissue | 100mg/sample, snap-frozen in liquid nitrogen and stored at -80°C. Ship on dry ice. |
| Cells | ≥1×106/sample, snap-frozen in liquid nitrogen and stored at -80°C. Ship on dry ice. |
| Feces and intestinal contents (wet weight) | 200 mg/sample; snap-frozen in liquid nitrogen and stored at -80°C. Ship on dry ice. |
| For other sample types, please get in touch with us. | |
| Note: For all samples, please avoid repeated freezing and thawing. | |
S1P defects cause a new entity of cataract, alopecia, oral mucosal disorder, and psoriasis-like syndrome
Journal: EMBO Molecular Medicine; IF：10.624;
Reference:
Chen F, Ni C, Wang X. et al. S1P defects cause a new entity of cataract, alopecia, oral mucosal disorder, and psoriasis-like syndrome. EMBO Mol Med. 2022 May 9;14(5):e14904. doi: 10.15252/emmm.202114904. Epub 2022 Apr 1. PMID: 35362222; PMCID: PMC9081911.
Please submit a detailed description of your project. We will provide you with a customized project plan metabolomics services to meet your research requests. You can also send emails directly to support-global@metwarebio.com for inquiries.
