TM Widely-Targeted Metabolomics

TM Widely-targeted metabolomics is the 'Untargeted metabolomics + Targeted Metabolomics' process that achieves the perfect combination of high resolution, wide-coverage, high sensitivity, and precise quantification. It is a great starting point to examine the global metabolite profile. Metware's curated database of 280,000 metabolites, which includes 3000 metabolites not found in public databases, allows more annotations from high-resolution mass spec data.

Technology Introduction

"TM" Widely-Targeted Metabolomics combines Untargeted metabolomics and Targeted metabolomics to achieve the perfect combination of high-resolution, wide-coverage, high-sensitivity, and precise quantification. Metware's patented Widely-Targeted Metabolomics technology stands out from many others with features such as:
  • Using high-resolution mass spectrometers to allow the unbiased collection of MS/MS spectrum data;
  • Highly curated metabolomics database with over 3000+ in-house metabolite database providing more metabolite annotation;
  • Using MRM analysis from QQQ to accurately quantify metabolites in each sample.

TM Widely-Targeted Matabolomics Service Technical Features

Large Curated Database
Collected ultra-high resolution data of over 280,000 metabolites. Each sample can typically identify over 1400 metabolites.
Rigorous Quality Control
A mature quality control system monitoring all aspects of experimentation from sample preparetion to data analysis.
Stable and tested sample preparation protocol stemming from processing over a million samples a year.
Accurate Identification
Combining AB SCIEX QTOF 6600+ ultra-high resolution mass spectrum with our large curated database to achieve accurate metabolite identification.
Accurate Quantification
Using MRM mode from AB SCIEX Triple Quad 6500+ to achieve accurate relative quantification of metabolites.

Applications of TM Widely-Targeted Matabolomics Service

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List of Metabolites

The in-house standard database contains 3000 metabolites as shown below:

Category Quantity Representative substance
Amino acids and their metabolites 600+ Glycine, L-threonine, L-arginine, N-acetyl-L-alanine
Organic acids and their derivatives 400+ 3-hydroxybutyric acid, adipic acid, hippuric acid, kynurenine
Nucleotides and their metabolites 200+ Adenine, 5'-Adenine Nucleotide, Guanine, 2'-Deoxycytidine
Carbohydrates and their metabolites 100+ D-glucose, glucosamine, D-fructose 6-phosphate
Lipid 500+ O-acetylcarnitine, γ-linolenic acid, lysophosphatidylcholine 22:4
Benzene and its derivatives 500+ Benzoic acid, 3,4-dimethoxyphenylacetic acid, 4-hydroxybenzoic acid
Coenzymes and vitamins 60+ Folic acid, pantothenic acid, vitamin D3
Alcohols, amines 150+ Dopamine, histamine, DL-1-amino-2-propanol
Aldehydes, ketones, esters 120+ Furfural, ethyl butyrate, α-pentyl cinnamaldehyde
Heterocyclic compound 200+ Pyridoxal, biopterin, indole-3-acetic acid
bile acid 40+ Glycocholic acid, deoxycholic acid, taurolithocholic acid
Hormones and hormone-related substances 100+ Juvenile hormone 3, epinephrine, 3,3'-diiodo-L-thyroxine
Tryptamine, choline, pigment 15+ Serotonin, bilirubin (E-E), urobilin
other 50+ Astaxanthin
total 3000+

Project Workflow of TM Widely-Targeted Matabolomics Service

Analysis Content Display of TM Widely-Targeted Metabolomics Service

Our complete service includes various data analyses to jump start your research. Below are a few components that you may find in our data analysis report.


Please submit a detailed description of your project. We will provide you with a customized project plan metabolomics services to meet your research requests. You can also send emails directly to support-global@metwarebio.com for inquiries.
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