Metware Biotechnology Co., Ltd.
TM Widely-Targeted Metabolomics

TM Widely-Targeted Metabolomics

tm widely targeted metabolomics service 1

TM Widely-targeted metabolomics is the 'Untargeted metabolomics + Targeted Metabolomics' process that achieves the perfect combination of high resolution, wide-coverage, high sensitivity, and precise quantification. It is a great starting point to examine the global metabolite profile. Metware's curated database of 280,000 metabolites, which includes 3000 metabolites not found in public databases, allows more annotations from high-resolution mass spec data. 

Technology Introduction

"TM" Widely-Targeted Metabolomics combines Untargeted metabolomics and Targeted metabolomics to achieve the perfect combination of high-resolution, wide-coverage, high-sensitivity, and precise quantification. Metware's patented Widely-Targeted Metabolomics technology stands out from many others with features such as:

  • Using high-resolution mass spectrometers to allow the unbiased collection of MS/MS spectrum data;

  • Highly curated metabolomics database with over 3000+ in-house metabolite database providing more metabolite annotation;

  • Using MRM analysis from QQQ to accurately quantify metabolites in each sample.


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TM Widely-Targeted Matabolomics Service Technical Features

Large Curated Database

Collected ultra-high resolution data of over 280,000 metabolites. Each sample can typically identify over 1400 metabolites.

Rigorous Quality Control

A mature quality control system monitoring all aspects of experimentation from sample preparetion to data analysis.

Experienced

Stable and tested sample preparation protocol stemming from processing over a million samples a year.

Accurate Identification

Combining AB SCIEX QTOF 6600+ ultra-high resolution mass spectrum with our large curated database to achieve accurate metabolite identification.

Accurate Quantification

Using MRM mode from AB SCIEX Triple Quad 6500+ to achieve accurate relative quantification of metabolites.

Applications of TM Widely-Targeted Matabolomics Service

  • Clinical marker discovery and development

  • Understanding mechanisms behind disease progression

  • Studying drug efficacy and toxicity

  • Environmental toxicology research

List of Metabolites

Our curated database contains over 280,000 metabolites. Our in-house standard database has over 3,000 metabolites. The integrated public database has over 150,000 metabolites, and the AI predictive structural database has over 130,000 metabolites. The integrated public databases include KEGG, HMDB, Metlin, Mass Bank, Lipid Search, and other commonly used databases.

List of Metabolites

The in-house standard database contains 3000 metabolites as shown below:

CategoryQuantityRepresentative substance
Amino acids and their metabolites600+Glycine, L-threonine, L-arginine, N-acetyl-L-alanine
Organic acids and their derivatives400+3-hydroxybutyric acid, adipic acid, hippuric acid, kynurenine
Nucleotides and their metabolites200+Adenine, 5'-Adenine Nucleotide, Guanine, 2'-Deoxycytidine
Carbohydrates and their metabolites100+D-glucose, glucosamine, D-fructose 6-phosphate
Lipid500+O-acetylcarnitine, γ-linolenic acid, lysophosphatidylcholine 22:4
Benzene and its derivatives500+Benzoic acid, 3,4-dimethoxyphenylacetic acid, 4-hydroxybenzoic acid
Coenzymes and vitamins60+Folic acid, pantothenic acid, vitamin D3
Alcohols, amines150+Dopamine, histamine, DL-1-amino-2-propanol
Aldehydes, ketones, esters120+Furfural, ethyl butyrate, α-pentyl cinnamaldehyde
Heterocyclic compound200+Pyridoxal, biopterin, indole-3-acetic acid
bile acid40+Glycocholic acid, deoxycholic acid, taurolithocholic acid
Hormones and hormone-related substances100+Juvenile hormone 3, epinephrine, 3,3'-diiodo-L-thyroxine
Tryptamine, choline, pigment15+Serotonin, bilirubin (E-E), urobilin
other50+Astaxanthin, hydroxyurea
total3000+


Project Workflow of TM Widely-Targeted Matabolomics Service

Project Workflow of TM Widely-Targeted Matabolomics Service

Analysis Content Display of TM Widely-Targeted Metabolomics Service

Our complete service includes various data analyses to jump start your research. Below are a few components that you may find in our data analysis report.
Analysis Content Display of TM Widely-Targeted Metabolomics Service
WHAT'S NEXT IN OMICS: THE METABOLOME
WHAT'S NEXT IN OMICS: THE METABOLOME

Please submit a detailed description of your project. We will provide you with a customized project plan metabolomics services to meet your research requests. You can also send emails directly to support-global@metwarebio.com for inquiries.