Metabolites

Ceramides vs Niacinamide: How They Strengthen the Skin Barrier

Nov 25, 2025

How do ceramides and niacinamide differ—and work together—in skin barrier biology? We compare SC ceramide subclasses, SPT-driven lipid synthesis, TEWL outcomes, and tape-strip lipidomics.

Isoprenoids Explained: Mevalonate (MVA) vs MEP Pathways, CoQ10 and Dolichol in Health and Disease

Nov 17, 2025

Learn how isoprenoids are built, how MVA vs MEP pathways feed CoQ10, dolichol and protein prenylation, and how to quantify them with targeted metabolomics.

Biological Waxes: Composition, Plant Cuticular Waxes, and GC-MS Profiling

Nov 10, 2025

Learn what biological and plant cuticular waxes are, their functions and composition, and how to profile them using GC-MS and GC×GC-MS—from sampling to data interpretation.

Isobutyric Acid (Isobutyrate): An Overlooked Branched SCFA in Gut Health & Disease

Nov 06, 2025

Learn how isobutyric acid (isobutyrate) signals protein fermentation, how it differs from butyrate, its links to IBD/NAFLD/CRC, and how to measure it (GC–MS vs LC–MS/MS).

ATP vs ADP: Structure, Energy, and What the Ratio Really Tells You

Nov 04, 2025

Differences between ATP and ADP, why ATP/ADP ratio and adenylate energy charge (AEC) matter, and practical measurement methods (luciferase, LC–MS/MS).

Indole: The Microbial Metabolite Connecting Gut Health, Brain, and Immunity

Oct 31, 2025

Understand indole's microbial origin, host metabolism, roles in IBD, brain inflammation & cancer—and how to measure key indole metabolites.

Trimethylamine N-oxide (TMAO): From Gut Microbiome Pathway to Cardiometabolic Risk

Oct 27, 2025

What is TMAO? Learn how diet, gut microbes and FMO3 shape TMAO levels; evidence for CVD/CKD/diabetes risk; how to lower TMAO; and how targeted LC–MS/MS panels quantify TMAO for research.

Methylmalonic Acid: From B12 Deficiency Indicator to Age-Linked Cancer Biomarker

Oct 23, 2025

Learn how methylmalonic acid (MMA) moves from B12 deficiency marker to age-linked oncometabolite, with testing, ranges, renal caveats, and LC–MS/MS tips.

Sphingosine: What It Is, Biosynthesis, and Roles in Health & Disease

Oct 13, 2025

Learn what sphingosine is, how it’s made and metabolized, how it differs from ceramide/S1P, and why it matters in skin defense, cancer, and neuroinflammation.

Glycophospholipids: The "Sugar-Fat" Lipids with Big Health Impacts

Sep 26, 2025

Understand glycophospholipids (incl. PtdGlc, GPI anchors): what they are, how they're made, health roles, and how to profile them with modern lipidomics.

Polyphenols Explained: How Plant Compounds Boost Health and Wellness

Sep 09, 2025

Learn what polyphenols are, how plants make them, how your body processes them, and how to measure them—plus evidence for cancer, heart and brain health.

Nucleosides: Structure, Functions, Biomarkers & LC–MS/MS Profiling

Sep 01, 2025

Learn nucleosides vs nucleotides, key functions, clinical and plant relevance, and LC–MS/MS profiling—actionable guidance for study design and biomarker discovery.

Water-Soluble Vitamins: Importance, Functions, and Analytical Measurement in Research

Aug 25, 2025

Clear guide to water-soluble vitamins (B-complex & vitamin C): key functions, deficiencies, disease links, and how to measure them accurately with LC–MS/MS.

What Is Sphingomyelin? Structure, Metabolism, and Its Role in Human Health

Aug 20, 2025

What sphingomyelin is, how it’s built and metabolized, why it matters for brain, cardiometabolic and immune health, plus food sources and lipidomics guidance.

Valeric Acid: A Small Molecule with Big Impacts on Human Health

Jul 24, 2025

Explore valeric acid's biosynthesis, health effects, and therapeutic roles in neurodegeneration, gut health, metabolism, and more.

Ceramide Metabolism: A Key Pathway in Lipid Signaling and Human Disease

Jul 09, 2025

Explore how ceramide metabolism connects lipid signaling with human disease, from diabetes to cancer. Understand key enzymes, pathways, and clinical insights.

The Mevalonate Pathway: Central Hub of Cholesterol Metabolism, Isoprenoid Biosynthesis, and Disease Mechanisms

Apr 27, 2025

Explore the mevalonate (MVA) pathway, a crucial metabolic route for cholesterol synthesis, isoprenoid production, and disease mechanisms. Learn about its regulation, biological roles, and implications in cancer, cardiovascular disease, and rare disorders.

Glycolysis vs. Gluconeogenesis: The Dual Engines of Glucose Metabolism

Apr 27, 2025

Explore glycolysis and gluconeogenesis—the key metabolic pathways for glucose breakdown and synthesis. Learn their regulation, roles in diseases like cancer & diabetes, and research applications. Discover MetwareBio’s metabolomics solutions for metabolic studies.

Methionine Metabolism: At the Crossroads of Methylation, Redox Balance, and Cellular Health

Apr 23, 2025

Explore how methionine metabolism links methylation, antioxidant defense, and disease pathways. Understand its central role in epigenetics, redox balance, and metabolic health.

What Are Nucleotides? Discover the Molecules Behind DNA, Immunity, and Vitality

Apr 22, 2025

Unlock the secrets of nucleotides—the essential molecules behind DNA, immunity, and energy. Learn their structure, synthesis, and vital role in health and disease.